XYLAZIL-20 produces dose dependent sedation and analgesia through an alphamimetic and direct opioid effect. It also produces muscle relaxation by inhibition of the intraneuronal transmission of impulses centrally in the CNS. Direct stimulation of the emetic centre results in emesis in most cats and occasionally in the dog.
Onset of action after intravenous injections rapid with effective sedation present within 3 - 5 minutes and after intramuscular
or subcutaneous administration, it occurs within 10 - 15 minutes. The sedative effect usually lasts 1 - 2 hours, while the analgesic effect lasts only 30 - 40 minutes. Complete recovery varies with the doses administered, however it is usually uneventful and requires minimal supervision.
An analgesic, sedative and muscle relaxant injection.
Directions for use
Sheep & Goats: XYLAZIL-20 is given in doses of 0.01-0.22mg/kg bodyweight (0.01-0.22 mL/20kg b.w.) by i.m.
Dogs & Cats: 0.5-1.0 mg/kg bodyweight (0.25-0.5 mL/10kg b.w.) by slow i.v. 1.0-2.2 mg/kg bodyweight (0.5-1.1mL/10kg b.w.) by i.m. or s.c.
For Dogs over 23kg: 1.1 mg/kg bodyweight (1.1mL/20kg b.w.)
Cattle: Ruminants are the most sensitive of the domestic animals to the action of xylazine. In cattle, dose levels required to produce deep sedation and analgesia are one tenth of those required in horses, dogs and cats.
XYLAZIL-20 is given in doses of 0.50 - 0.75mL/100kg bodyweight i.m., or 0.15 - 0.75mL/100kg bodyweight by slow i.v., depending upon degree of sedation required.
Mild sedation: With this dosage, the animals should remain standing. Suitable for procedures such as clinical examination, transportation, rectal examination, weighing, radiography, bandaging etc. Also as an adjunct to local anaesthesia for standing surgery and as a premedicant for general anaesthesia.
Moderate sedation: With this dosage, moderate analgesia and muscle relaxation are obtained. The animal will remain standing in most cases, however, recumbency may occur. Suitable for general usage.
Deep sedation: With this dosage, heavy analgesia and muscle relaxation will occur, causing recumbency. Suitable for major surgery such as claw amputation, caesarean section, eye ablation etc in conjunction with appropriate local anaesthesia, as well as physical restraint
of fractious animals.
Injection 20mL and 50mL.
Xylazine as hydrochloride 20mg/mL. (2% w/v).
It is normal for XYLAZIL-20 to cause cardiopulmonary depression manifested by a decrease in heart rate, stroke volume, cardiac output and respiratory rate together with an increase in total peripheral resistance. The effects are transitory and of no clinical significance in healthy animals, however it is not recommended to use XYLAZIL-20 where there
is cardiovascular disease including conditions of shock or respiratory depression.
Salivation, hyperthermia, transient diarrhoea and ruminal atony may be observed. It is not recommended that sedated animals be left in an environment where overheating could occur due to inability to adequately thermo regulate. In cattle, temperature elevation is highest 4 - 5 hours after intramuscular injection, and slowly returns to pre-injection levels around 14 hours later.
Atropine premedication may help prevent excessive salivation in ruminants. Normal precautions in relation to prolonged recumbency should be observed in ruminants to avoid bloating, ruminal atony, regurgitation and aspiration pneumonia.
XYLAZIL-20 should not be administered to animals in the last month of pregnancy as it may precipitate an early parturition or abortion. It should not be administered intra-arterially and it should not be given to dogs or cats in conditions where emesis is undesirable e.g. gastric dilation and torsion, ingestion of caustic liquid or sharp foreign objects.
Meat – Do not use less than 28 days before slaughter for human consumption.
Milk – Nil.
Store below 30ºC (room temperature).