Enrofloxacin is a fluoroquinolone antimicrobial. It has rapid bactericidal activity against a broad spectrum of bacteria, it is effective against gram positive and gram negative bacteria and mycoplasmas. It is active at low concentrations compared with other classes of antimicrobial agents. Therefore, Enrofloxacin is active against the micro organisms that are primarily or secondarily involved in many of the infectious diseases that occur in small animals.
Primary indications for use in the dog and cat are:
♦ Urinary tract infections, including infections with E. coli, Proteus spp., Klebsiella spp., Pseudomonas aeruginosa, Staph spp., and Group D Streptococcus.
♦ Respiratory infections, including infections with E. coli, Streptococcus spp, Pasturella spp, Klebsiella spp, Pseudomonas spp, Bordetella bronchiseptica, Staphylococcus spp.
♦ Deep pyodermas caused by Staph. Intermedius including those infected with secondary invaders.
♦ Wounds, abscesses and discharging sinuses.
♦ Deep pyodermas, osteomylitis and Gram negative septicaemias.
♦ Ilium Enrotril is useful for treating serious antibiotic resistant infections of the respiratory tract or genitourinary system, particularly chronic urinary tract infections in cats.
Ilium Enrotril may also be used in exotic animals, small mammals, reptiles and avian species, to treat bacterial infections of the alimentary and respiratory tracts where clinical experience, supported where possible by sensitivity testing of the casual organism, indicates enrofloxacin as the drug of choice.
For use only in companion animals where culture and sensitivity testing indicate no suitable alternative.
Directions for use
Use the contents of the vial within six months of initial broaching. Discard the unused portion.
Dogs and Cats:
The optimum dose of Ilium Enrotril for dogs and cats is 5mg/kg of bodyweight (equivalent to 1ml/10kg bodyweight) administered once daily by subcutaneous injection.
For the treatment of simple infections, Ilium Enrotril Antibacterial injection may be used as the initial dose, with continued daily oral enrofloxacin dosage up to 2-3 days beyond the cessation of clinical signs.
If no improvement is seen within five days, the diagnosis should be re-evaluated and a different course of therapy considered.
In deep or complex infections eg. Pyodermas, discharging sinuses, extended courses may be required and progress should be regularly reviewed.
Exotic animals: In the absence of data, the following dosage and administration instructions may be suitable for exotic animals.
Small mammals, 5mg/kg, subcutaneously or orally, twice daily for 7 days.
Reptiles, 5mg/kg, intramuscularly or orally at 24-48 hour intervals for 6 days.
Avian, 10mg/kg, intramuscularly or orally, twice daily for 7 days.
Treatment may be initiated with Ilium Enrotril Anitbacterial Injection and should be maintained by oral enrofloxacin dosage forms as appropriate.
In all cases, the use of a tuberculin or insulin syringe and or dilution of Ilium Enrotril with sterile water for injection should be considered for administration of very small volumes.
In all species vary the injection site when multiple injections are given.
Injection 50mL vial
Dogs: the use of enrofloxacin is contraindicated in dogs during the rapid growth phase. Ilium Enrotril should not be used in dogs under one (1) year of age. Giant breeds may be in the rapid growth phase for up to 18 months. Care should be used in treating individuals of these breeds with Ilium Enrotril when they are younger than 18 months.
Cats: Ilium Enrotril should not be used in cats less than 12 weeks of age. The safe use of enrofloxacin in breeding female cats has not been established.
DO NOT USE in FOOD producing animals.
Although rare, it is prudent to consider that any fluoroquinolone may have the potential to induce retinal degeneration in cats, especially when used above label dose rates or in animals that are elderly or suffering from renal or hepatic disease.
Dogs: The principle adverse reaction cited in adult dogs was vomiting and crystalluria. Two cases of vomiting recorded out of 270 dogs treated with oral enrofloxacin have been reported in the literature. Subsequent studies involving treatment of 122 cases with injectable enrofloxacin, followed by oral enrofloxacin report no drug related side effects.
Cats: No drug related side effects following the administration of oral enrofloxacin are reported in the scientific literature.
Exotic animals: Muscle bruising in reptiles and birds following injection has been reported occasionally.
Store Below 30ºC (room temperature).