Anaesthetic for Dogs and Cats
Pacifol Anaesthetic for Dogs and Cats is an oil-in-water, isotonic emulsion for intravenous injection, containing 10mg Propofol per mL.
Pacifol is a short acting intravenous General Anaesthetic for Dogs and Cats.
Use for procedures of short duration, lasting up to 5 minutes, induction and maintenance of general anaesthesia using incremental doses to effect or induction of general anaesthesia where maintenance is provided by inhalation anaesthetic.
Pacifol is compatible with a wide variety of commonly used pre-anaesthetic agents. The dose of propofol required to induce anaesthesia is significantly reduced by the administration of pre-anaesthetic agents prior to induction. Unlike barbiturates, no evidence of tissue irritation or reaction has been observed following accidental perivascular administration of propofol.
Pacifol is particularly suitable for cases where a short recovery period is desired.
Directions for use
Administer by intravenous injection only. The following dose rates are a guide only. Pacifol should be administered to effect. The required dose of Pacifol is reduced by the administration of pre-anaesthetic agents.The induction dose is calculated according to bodyweight and may be administered to effect over a period of 10-40 seconds. Alternatively, the calculated dose may be given in full as a single bolus. The induction dose is reduced by the use of premedicants. The following dose rates are for guidance and in practice the dose rate should be based on response. The average induction dose for dogs and cats, either un-premedicated or when premedicated with a tranquilliser such as acepromazine, is as follows:
Dogs: unpremedicated 6.5mg/kg bodyweight, or 6.5ml/10kg bodyweight.
Premedicated 4.0mg/kg bodyweight, or 4.0ml/10kg bodyweight.
Cats: unpremedicated 8.0mg/kg bodyweight or 2.0ml/2.5kg bodyweight
Premedicated 6.0mg/kg bodyweight, or 1.5ml/2.5kg bodyweight.
Where anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Incremental doses should be given to effect. Doses of approximately 1ml per 4.0-8.0kg bodyweight sustain anaesthesia for periods of up to 5 minutes.
Where inhalation agents are used to maintain general anaesthesia, clinical experience indicates that there may be a need to use a higher initial concentration of inhalation agent than is normally the case following induction with barbiturate agents such as thiopentone.
20 mL and 50mL multidose vials.
The emulsion should not be mixed with other therapeutic agents or infusion fluids prior to administration.
During induction of anaesthesia, mild hypotension and transient apnoea, similar to effects with other intravenous anaesthetic agents may occur. When using Pacifol, facilities for the maintenance of a patient airway, artificial ventilation and oxygen enrichment should be available.
As with other intravenous anaesthetic agents, caution should be exercised in dogs and cats with cardiac, respiratory, renal or hepatic impairment, or in hypovolaemic or debilitated animals.
Pacifol has not been used in dogs and cats where the pregnancy is to be maintained, but has been used successfully for induction prior to Caesarean section in bitches.
If Pacifol is injected very slowly, an inadequate plane of anaesthesia can occur.
Adverse reactions during induction, maintenance and recovery are uncommon. Induction is generally smooth, with minimal evidence of excitation. During the recovery phase, vomiting and evidence of excitation have been observed in a small proportion of animals.
In clinical trials in cats, transient apnoea during induction and a paw/face licking characteristic during recovery have been observed in a small proportion of cases. If panting is evident before induction, it may continue throughout the subsequent periods of anaesthesia and recovery.
Accidental over-dosage is likely to cause cardio-respiratory depression. Respiratory depression should be treated by artificial ventilation and oxygen. Cardiovascular depression requires the use of plasma expanders and pressor agents.
Not to be used in food-producing species of animals.
Store below 30ºC (room temperature). Do not freeze. Protect from light. Any portion of the contents remaining after use should be discarded.